Receptor 4 in Ovarian Carcinoma Microenvironmental Regulation of Chemokine (C-X-C-Motif)
نویسندگان
چکیده
Authors' A University Biological Chemistry, Pathology Missouri Correspon ceutical Sc Street, PH 312-996-00
منابع مشابه
Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma.
The majority of women diagnosed with epithelial ovarian carcinoma (EOC) succumb due to complications of metastatic disease, suggesting that antimetastatic therapies may improve patient survival. EOC metastasis involves intraperitoneal shedding of cells from the primary tumor, followed by adhesion and localized penetration of the submesothelial matrix to anchor metastatic implants. Accumulation ...
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Cancer stem cells (CSCs, also called cancer stem-like cells, CSLCs) can function as "seed cells" for tumor recurrence and metastasis. Here, we report that, in the presence of CD133+ ovarian CSLCs, CD133- non-CSLCs can undergo an epithelial-mesenchymal transition (EMT)-like process and display enhanced metastatic capacity in vitro and in vivo. Highly elevated expression of chemokine (C-C motif) ...
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تاریخ انتشار 2010